| 1. |
Establishment for methods for extraction, separation and structural determination
of endogenous peptides |
| 1.1 |
Establishment for methods for extraction, separation and structural determination
of endogenous peptides |
|
Naoto, Minamino, National Cardiovascular Center Research Institute |
|
Calcitonin receptor-stimulating peptides |
|
|
| 1.2 |
High-sensitivity structural analysis of biological peptides by mass spectrometry |
|
Toshifumi Takao, nstitute for Protein Research, Osaka University |
|
Software aid for mass spectrometry |
|
|
| 2. |
Research for biological activities and structure of endogenous peptides
and receptors |
| 2.1 |
Highly efficient discovery system for biologically active peptides using
cultured cells and orphan G protein-coupled receptors |
|
Kenji Kangawa, National Cardiovascular Center Research Institute |
|
Measurement of biological activities by extracellular pH shift |
|
Measurement of biological activities by increse in intracellular Ca |
|
Measurement of biological activities by intracellular cAMP shift - alpha
Screen Method |
|
Measurement of biological activities by intracellular cAMP shift - Reporter
gene Method |
|
|
| 2.2 |
Isolation and characterization of bioactive peptides using functional nd
developmental assay systems. |
|
Tai Kubo, National Institute of Advanced Industrial Science and Technology |
|
Novel Bioactive Peptides, Pilosulin 3 and Pilosulin 4 |
|
GPCR Catalog |
|
|
| 2.3 |
Sensitive and high throughput ligand-screening system of G protein-coupled
receptors. |
|
Tatsuya Haga, Faculty of Science, Gakushuin University |
|
The Receptor-Ga Fusion as a Tool for Ligand Screening |
|
|
| 2.4 |
Structural modeling of peptides and peptide receptors for drug design |
|
Masaji Ishiguro, Suntory Institute for Bioorganic Research |
|
Peptide Conformation Database |
|
|
